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Levels of myeloid-related proteins in saliva for screening and monitoring of periodontal disease

Lookup NU author(s): Dr Susan BissettORCiD, Professor Philip Preshaw, Dr John TaylorORCiD

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Abstract

© 2021 The Authors. Journal of Clinical Periodontology published by John Wiley & Sons Ltd. Aim: To evaluate the salivary levels of myeloid-related markers in relation to periodontal disease and their potential screening capability, as well as the effects of periodontal treatment on these markers in periodontitis patients. Materials and methods: Participants with a healthy periodontium (n = 60) and with gingivitis (n = 63) and periodontitis (n = 72) were recruited. Periodontitis patients received non-surgical treatment and were re-examined after 3 and 6 months. Unstimulated saliva was collected at baseline and at 1, 3, and 6 months after therapy for the periodontitis patients. Levels of colony-stimulating factor-1 (CSF-1), interleukin-34 (IL-34), S100A8/A9, S100A12, hepatocyte growth factor (HGF), IL-1β, and matrix metalloproteinase-8 (MMP-8) were analysed by immunoassays. Results: CSF-1, S100A8/A9, S100A12, IL-1β, MMP-8, and HGF were significantly elevated in saliva from periodontitis and gingivitis patients in comparison to healthy individuals, whereas IL-34 was significantly lower in periodontitis compared to both healthy individuals and gingivitis patients. IL-34 increased significantly 3 months after treatment, while IL-1β and MMP-8 decreased 1 month after therapy. Additionally, periodontitis patients clustered in high and low levels of S100A8/A9, whereby those with high levels had more bleeding, deeper pockets, and higher S100A12. Conclusions: Salivary levels of myeloid-related markers are altered in periodontitis and are partially modulated by periodontal treatment. Measuring S100A8/A9 in saliva may identify distinct groups of periodontitis patients.

Publication metadata

Author(s): Lira-Junior R, Bissett SM, Preshaw PM, Taylor JJ, Bostrom EA

Publication type: Article

Publication status: Published

Journal: Journal of Clinical Periodontology

Year: 2021

Volume: 48

Issue: 11

Pages: 1430-1440

Print publication date: 01/11/2021

Online publication date: 18/08/2021

Acceptance date: 25/07/2021

Date deposited: 22/09/2021

ISSN (print): 0303-6979

ISSN (electronic): 1600-051X

Publisher: John Wiley and Sons Inc.

URL: https://doi.org/10.1111/jcpe.13534

DOI: 10.1111/jcpe.13534

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