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A global approach to long-term follow-up of targeted and immune-based therapy in childhood and adolescence

Lookup NU author(s): Professor Andrew Pearson, Professor Roderick Skinner

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Abstract

© 2021 Wiley Periodicals LLCWhile considerable efforts and progress in our understanding of the long-term toxicities of surgery, radiation and chemotherapy in children with cancer have been made over the last 5 decades, there continues to be a wide gap in our knowledge of the long-term health impact of most novel targeted and immunotherapy agents. To address this gap, ACCELERATE, a multi-stakeholder collaboration of clinical and translational academics, regulators from the EMA and FDA, patient/family advocates and members spanning small biotechnology through to large pharmaceutical companies have initiated the development of an international long-term follow-up data registry to collect this important information prospectively. Providing critical safety data on the long-term use of these approved and investigational therapies in children will support the regulatory requirements and labeling information. It will also provide the necessary insight to help guide physicians and families on the appropriateness of a targeted or immune therapy for their child and inform survivorship planning.

Publication metadata

Author(s): Kieran MW, Caron H, Winther JF, Henderson TO, Haupt R, Hjorth L, Hudson MM, Kremer LCM, van der Pal HJ, Pearson ADJ, Pereira L, Reaman G, Skinner R, Vassal G, Weiner SL, Horton Taylor D

Publication type: Note

Publication status: Published

Journal: Pediatric Blood and Cancer

Year: 2021

Volume: 68

Issue: 7

Print publication date: 01/07/2021

Online publication date: 16/04/2021

Acceptance date: 18/03/2021

ISSN (print): 1545-5009

ISSN (electronic): 1545-5017

Publisher: John Wiley and Sons Inc

URL: https://doi.org/10.1002/pbc.29047

DOI: 10.1002/pbc.29047

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