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Carbogen inhalation during Non-Convulsive Status Epilepticus: A quantitative exploratory analysis of EEG recordings

Lookup NU author(s): Dr Sriharsha Ramaraju, Professor Yujiang WangORCiD, Dr Rob ForsythORCiD, Professor Peter TaylorORCiD

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Abstract

Objective: To quantify the effect of inhaled 5% carbon-dioxide/95% oxygen on EEG recordings from patients in non-convulsive status epilepticus (NCSE).Methods: Five children of mixed aetiology in NCSE were given high flow of inhaled carbogen (5% carbon dioxide/95% oxygen) using a face mask for maximum 120s. EEG was recorded concurrently in all patients. The effects of inhaled carbogen on patient EEG recordings were investigated using band-power, functional connectivity and graph theory measures. Carbogen effect was quantified by measuring effect size (Cohen’s d) between “before”, “during” and “after” carbogen delivery states.Results: Carbogen’s apparent effect on EEG band-power and network metrics across all patients for “before-during” and “before-after” inhalation comparisons was inconsistent across the five patients.Conclusion: The changes in different measures suggest a potentially non-homogeneous effect of carbogen on the patients’ EEG. Different aetiology and duration of the inhalation may underlie these non-homogeneous effects. Tuning the carbogen parameters (such as ratio between CO2 and O2, duration of inhalation) on a personalised basis may improve seizure suppression in future.

Publication metadata

Author(s): Ramaraju S, Reichert S, Wang Y, Forsyth R, Taylor PN

Publication type: Article

Publication status: Published

Journal: PLoS one

Year: 2021

Volume: 16

Issue: 2

Online publication date: 02/03/2021

Acceptance date: 12/09/2020

Date deposited: 27/10/2020

ISSN (electronic): 1932-6203

Publisher: Public Library of Science

URL: https://doi.org/10.1371/journal.pone.0240507

DOI: 10.1371/journal.pone.0240507

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