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Changes in quality of life, health status, and other patient-reported outcomes following Simultaneous Pancreas and Kidney Transplantation (SPKT): a quantitative and qualitative analysis within a UK-wide programme

Lookup NU author(s): Dr Charlie Tomson

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

This article is protected by copyright. All rights reserved.We examined quality of life (QoL) and other patient-reported outcome measures (PROMs) in 95 Simultaneous Pancreas and Kidney Transplant (SPKT) recipients and 41 patients wait-listed for SPKT recruited to the UK Access to Transplantation and Transplant Outcome Measures (ATTOM) programme. Wait-listed patients transplanted within 12 months of recruitment (n=22) were followed 12-months post-transplant and compared with those still wait-listed (n=19) to examine pre-to-post-transplant changes. Qualitative interviews with ten SPKT recipients 12-months post-transplant were analysed thematically. Cross-sectional analyses showed several better 12-month outcomes for SPKT recipients compared with those still wait-listed, a trend to better health utilities but no difference in diabetes-specific QoL or diabetes treatment satisfaction. Pre- to post-transplant, SPKT recipients showed improved treatment satisfaction, well-being, self-reported health, generic QoL and less negative impact on renal-specific QoL (ps<0.05). Health-utility values were better overall in transplant recipients and neither these nor diabetes-specific QoL changed significantly in either group. Pre-emptive transplant advantages seen in 12-month cross-sectional analyses disappeared when controlling for baseline values. Qualitative findings indicated diabetes complications, self-imposed blood-glucose monitoring and dietary restrictions continued to impact QoL negatively post-transplant. Unrealistic expectations of SPKT caused some disappointment. Measuring condition-specific PROMs over time will help in demonstrating the benefits and limitations of SPKT.

Publication metadata

Author(s): Gibbons A, Cinnirella M, Bayfield J, Watson CJE, Oniscu GC, Draper H, Tomson CRV, Ravanan R, Johnson RJ, Forsythe J, Dudley C, Metcalfe W, Bradley JA, Bradley C

Publication type: Article

Publication status: Published

Journal: Transplant International: Official Journal of the European Society for Organ Transplantation

Year: 2020

Volume: 33

Issue: 10

Pages: 1230-1243

Print publication date: 01/10/2020

Online publication date: 20/06/2020

Acceptance date: 20/06/2020

Date deposited: 12/07/2021

ISSN (print): 0934-0874

ISSN (electronic): 1432-2277

Publisher: Wiley

URL: https://doi.org/10.1111/tri.13677

DOI: 10.1111/tri.13677

PubMed id: 32562558

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