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Isolation and Characterization of Innate Lymphoid Cells within the Murine Tumor Microenvironment

Lookup NU author(s): Grace Mallett, Warren Patterson, Megan Payne, Professor Shoba AmarnathORCiD

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Abstract

© 2020, Springer Science+Business Media, LLC, part of Springer Nature.Innate lymphoid cells (ILCs) are important for both tissue immunity and tissue homeostasis. They are classified into three groups: Group 1 ILCs include NK cells, which are important in eliciting immunity against intracellular pathogens; group 2 ILCs protect against parasitic helminths; and group 3 ILCs protect against extracellular pathogens. The role of ILCs in cancer immunity remains unclear. In this chapter, we discuss methods for isolating and characterizing tumor-infiltrating ILC subsets within the tumor microenvironment in an experimental murine model of B16 melanoma. The chapter also highlights the expression of PD-1 on the various ILC subsets within the tumor microenvironment.

Publication metadata

Author(s): Mallett G, Patterson W, Payne M, Amarnath S

Publication type: Book Chapter

Publication status: Published

Book Title: Methods in Molecular Biology

Year: 2020

Volume: 2121

Pages: 153-164

Online publication date: 09/03/2020

Acceptance date: 02/04/2018

Publisher: Humana Press Inc.

Place Published: New York

URL: https://doi.org/10.1007/978-1-0716-0338-3_14

DOI: 10.1007/978-1-0716-0338-3_14

PubMed id: 32147794

Library holdings: Search Newcastle University Library for this item

ISBN: 9781071603383

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