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Separating and Segregating the Human Mitochondrial Genome

Lookup NU author(s): Dr Thomas NichollsORCiD

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Abstract

Cells contain thousands of copies of the mitochondrial genome. These genomes are distributed within the tubular mitochondrial network, which is itself spread across the cytosol of the cell. Mitochondrial DNA (mtDNA) replication occurs throughout the cell cycle and ensures that cells maintain a sufficient number of mtDNA copies. At replication termination the genomes must be resolved and segregated within the mitochondrial network. Defects in mtDNA replication and segregation are a cause of human mitochondrial disease associated with failure of cellular energy production. This review focuses upon recent developments on how mitochondrial genomes are physically separated at the end of DNA replication, and how these genomes are subsequently segregated and distributed around the mitochondrial network.

Publication metadata

Author(s): Nicholls TJ, Gustafsson CM

Publication type: Review

Publication status: Published

Journal: Trends in Biochemical Sciences

Year: 2018

Volume: 43

Issue: 11

Pages: 869-881

Print publication date: 01/11/2018

Online publication date: 14/09/2018

Acceptance date: 01/09/2018

ISSN (print): 0968-0004

ISSN (electronic): 1362-4326

URL: https://doi.org/10.1016/j.tibs.2018.08.007

DOI: 10.1016/j.tibs.2018.08.007

PubMed id: 30224181

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