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Myeloproliferative Neoplasms in Children and Adolescents and Thrombosis at Unusual Sites: The Role of Driver Mutations

Lookup NU author(s): Dr Kathryn Musgrave, Dr Peter Carey, Dr Tina Biss

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Abstract

© 2019 Lippincott Williams and Wilkins. All rights reserved.Myeloproliferative neoplasms (MPNs) in childhood and adolescence are rare and seldom complicated by thrombosis. We describe 3 cases of thrombosis at unusual sites in young patients with MPNs. In the pediatric MPN population, unlike in adult MPNs, a clonal mutation is identifiable in only a minority of cases (22% to 26%). All 3 of these individuals had JAK2 mutations driving the disease process. A literature search identified 19 cases of MPN-associated thrombosis in children. Seventeen of the 19 children (89.5%) had a driver mutation. These cases suggest that identifiable driver mutations may confer an increased thrombotic risk in children with MPNs.

Publication metadata

Author(s): Tafesh L, Musgrave K, Roberts W, Plews D, Carey P, Biss T

Publication type: Article

Publication status: Published

Journal: Journal of Pediatric Hematology/Oncology

Year: 2019

Volume: 41

Issue: 6

Pages: 490-493

Print publication date: 01/08/2019

Acceptance date: 20/03/2018

ISSN (print): 1077-4114

ISSN (electronic): 1536-3678

Publisher: Lippincott Williams and Wilkins

URL: https://doi.org/10.1097/MPH.0000000000001173

DOI: 10.1097/MPH.0000000000001173

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