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Microsporidian genomes harbor a diverse array of transposable elements that demonstrate an ancestry of horizontal exchange with metazoans

Lookup NU author(s): Dr Johan PanekORCiD

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Abstract

Microsporidian genomes are the leading models to understand the streamlining in response to a pathogenic lifestyle; they are gene-poor and often possess small genomes. In this study, we show a feature of microsporidian genomes that contrasts this pattern of genome reduction. Specifically, genome investigations targeted at Anncaliia algerae, a human pathogen with a genome size of 23 Mb, revealed the presence of a hitherto undetected diversity in transposable elements (TEs). A total of 240 TE families per genome were identified, exceeding that found in many free-living fungi, and searches of microsporidian species revealed that these mobile elements represent a significant portion of their coding repertoire. Their phylogenetic analysis revealed that many cases of ancestry involve recent and bidirectional horizontal transfers with metazoans. The abundance and horizontal transfer …

Publication metadata

Author(s): Parisot N, Pelin A, Gasc X, Polonais V, Belkorchia A, Panek J, El Alaoui H, Biron DG, Brasset E, Vaury C, Peyret P, Corradi N, Peyretaillade E, Lerat E

Publication type: Article

Publication status: Published

Journal: Genome Biology and Evolution

Year: 2014

Volume: 6

Issue: 6

Pages: 2289-2300

Print publication date: 01/09/2014

Online publication date: 28/08/2014

Acceptance date: 12/08/2014

Date deposited: 19/07/2019

ISSN (electronic): 1759-6653

Publisher: Oxford University Press

URL: https://doi.org/10.1093/gbe/evu178

DOI: 10.1093/gbe/evu178

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