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Fluorogenic L-alanylaminopeptidase substrates derived from 6-amino-2-hetarylquinolines and 7-amino-3-hetarylcoumarins and their potential applications in diagnostic microbiology

Lookup NU author(s): Dr John Perry

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Abstract

© 2019 Elsevier Ltd. Six novel fluorogenic enzyme substrates for detecting L-alanylaminopeptidase activity in microorganisms have been prepared and evaluated in Columbia agar media. The substrates are L-alanyl derivatives of 6-amino-2-hetarylquinolines and 7-amino-3-hetarylcoumarins. Both the quinoline and coumarin series of substrates produced fluorescence in the presence of Gram-negative microorganisms. In contrast, fluorescence generation in the presence of the Gram-positive microorganisms and yeasts was limited or absent.

Publication metadata

Author(s): Cellier-Rastit M, James AL, Orenga S, Perry JD, Robinson SN, Turnbull G, Stanforth SP

Publication type: Article

Publication status: Published

Journal: Bioorganic and Medicinal Chemistry Letters

Year: 2019

Volume: 29

Issue: 10

Pages: 1227-1231

Print publication date: 15/05/2019

Online publication date: 09/03/2019

Acceptance date: 09/03/2019

ISSN (print): 0960-894X

ISSN (electronic): 1464-3405

Publisher: Elsevier Ltd

URL: https://doi.org/10.1016/j.bmcl.2019.03.011

DOI: 10.1016/j.bmcl.2019.03.011

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