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Cell-free mitochondrial DNA in progressive multiple sclerosis

Lookup NU author(s): Hannah Lowes, Dr Angela Pyle, Dr Duddy Duddy, Professor Gavin HudsonORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

© 2018 Recent studies have linked cell-free mitochondrial DNA (ccf-mtDNA) to neurodegeneration in both Alzheimer's and Parkinson's disease, raising the possibility that the same phenomenon could be seen in other diseases which manifest a neurodegenerative component. Here, we assessed the role of circulating cell-free mitochondrial DNA (ccf-mtDNA) in end-stage progressive multiple sclerosis (PMS), where neurodegeneration is evident, contrasting both ventricular cerebral spinal fluid ccf-mtDNA abundance and integrity between PMS cases and controls, and correlating ccf-mtDNA levels to known protein markers of neurodegeneration and PMS. Our data indicate that reduced ccf-mtDNA is a component of PMS, concluding that it may indeed be a hallmark of broader neurodegeneration.

Publication metadata

Author(s): Lowes H, Pyle A, Duddy M, Hudson G

Publication type: Article

Publication status: Published

Journal: Mitochondrion

Year: 2019

Volume: 46

Pages: 307-312

Print publication date: 01/05/2019

Online publication date: 08/08/2018

Acceptance date: 31/07/2018

Date deposited: 29/08/2018

ISSN (print): 1567-7249

ISSN (electronic): 1872-8278

Publisher: Elsevier BV

URL: https://doi.org/10.1016/j.mito.2018.07.008

DOI: 10.1016/j.mito.2018.07.008

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