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Association between CYP4F2 genotype and circulating plasma vitamin K concentration in children on chronic warfarin therapy: Possible long-term implications for bone development and vascular health

Lookup NU author(s): Dr Emma KampourakiORCiD, Dr Peter Avery, Dr Tina Biss, Professor Farhad Kamali

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Abstract

© 2017 Wiley Periodicals, Inc. Vitamin K is essential, for the activation of clotting proteins, as well as the biosynthesis of osteocalcin in bones and the activation of matrix-Gla protein needed in maintaining vasculature health. Cytochrome p450 4F2 (CYP4F2) enzyme is involved in vitamin K catabolism. Genetic polymorphism in CYP4F2 is thus likely to affect vitamin K systemic availability. We show that children on chronic warfarin therapy have low levels of vitamin K and vitamin K levels are linked to CYP4F2 genotype. Long-term low levels of vitamin K, influenced by CYP4F2 genotype, might affect bone development and vascular health in children on chronic warfarin therapy.

Publication metadata

Author(s): Kampouraki E, Avery PJ, Biss T, Kamali F

Publication type: Article

Publication status: Published

Journal: Pediatric Blood and Cancer

Year: 2017

Volume: 64

Issue: 12

Print publication date: 01/12/2017

Online publication date: 18/05/2017

Acceptance date: 03/05/2017

ISSN (print): 1545-5009

ISSN (electronic): 1545-5017

Publisher: John Wiley and Sons Inc.

URL: https://doi.org/10.1002/pbc.26653

DOI: 10.1002/pbc.26653

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