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Covalent diphenylalanine peptide nanotube conjugated to folic acid/magnetic nanoparticles for anti-cancer drug delivery

Lookup NU author(s): Dr Cindy LeeORCiD

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Abstract

Micro and nanotubes obtained from the self-assembly of diphenylalanine peptides (FNTs) were conjugatedto folic acid/magnetic nanoparticles (FA/MNPs) and evaluated as a potential system for anti-cancerdrug delivery. The conjugates were obtained by providing a covalent linkage through the amine groupson FNTs with the carboxylic groups on FA/MNPs. The anti-cancer therapeutic 5-fluorouracil (5-FU), andanti-inflammatory cargo flufenamic acid (FFA), were loaded in peptide arrays during their self-assemblyin the liquid phase. AFM and CLSM analysis indicated the presence of FA aggregates on FNTs. The datarevealed that the cargo 5-FU, was distributed in dendrite peptide nanotubes whereas the non-polar cargoFFA, was homogeneously embedded in the structure of large discrete micro tubes. FTIR spectra of FAMNPs/FNTs showed peak of amide II at 1623 cm-1 indicating covalent interactions between aminesand carboxylic groups and confirmed the successful conjugation of the nanoparticles and peptide assemblies.The results indicated that 5-FU has been released from FNTs within 4 h, and incorporation of 5-FU in FNTs hydrogels has significantly slowed the release rate within the first 2 h. Our approach offers anew pathway for cancer treatment in which several functionalities are embedded in a single carrier.

Publication metadata

Author(s): Emtiazi G, Zohrabi T, Lee LY, Habibi N, Zarrabi A

Publication type: Article

Publication status: Published

Journal: Journal of Drug Delivery Science and Technology

Year: 2017

Volume: 41

Pages: 90-98

Print publication date: 01/10/2017

Online publication date: 07/06/2017

Acceptance date: 06/06/2017

ISSN (print): 1773-2247

ISSN (electronic): 2588-8943

Publisher: Elsevier BV

URL: http://dx.doi.org/10.1016/j.jddst.2017.06.005

DOI: 10.1016/j.jddst.2017.06.005

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