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New platforms for multi-functional ocular lenses: Engineering double-sided functionalized nano-coatings

Lookup NU author(s): Professor Ciara O'Sullivan, Professor Moein MoghimiORCiD

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Abstract

© 2015 Informa UK Ltd. All rights reserved.A scalable platform to prepare multi-functional ocular lenses is demonstrated. Using rapidly dissolving polyvinylpyrrolidone (PVP) as the active stabilizing matrix, both sides of ocular lenses were coated using a modified scaled-up masking electrohydrodynamic atomization (EHDA) technique (flow rates variable between 5 and 10 μL/min, applied voltage 4-11 kV). Each side was coated (using a specially designed flip-able well) selectively with a pre-determined morphology and model drug substance. PVP nanoparticles (inner side, to be in contact with the cornea, mean size

Publication metadata

Author(s): Mehta P, Justo L, Walsh S, Arshad MS, Wilson CG, O'Sullivan CK, Moghimi SM, Vizirianakis IS, Avgoustakis K, Fatouros DG, Ahmad Z

Publication type: Article

Publication status: Published

Journal: Journal of Drug Targeting

Year: 2015

Volume: 23

Issue: 4

Pages: 305-310

Online publication date: 13/01/2015

Acceptance date: 18/12/2014

ISSN (print): 1061-186X

ISSN (electronic): 1029-2330

Publisher: Informa Healthcare

URL: https://doi.org/10.3109/1061186X.2014.1001395

DOI: 10.3109/1061186X.2014.1001395

PubMed id: 25582133

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