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Epigenetics and Liver Fibrosis

Lookup NU author(s): Dr Eva Moran Salvador, Professor Jelena Mann

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).

Abstract

© 2017 The Authors Liver fibrosis arises because prolonged injury combined with excessive scar deposition within hepatic parenchyma arising from overactive wound healing response mediated by activated myofibroblasts. Fibrosis is the common end point for any type of chronic liver injury including alcoholic liver disease, nonalcoholic fatty liver disease, viral hepatitis, and cholestatic liver diseases. Although genetic influences are important, it is epigenetic mechanisms that have been shown to orchestrate many aspects of fibrogenesis in the liver. New discoveries in the field are leading toward the development of epigenetic biomarkers and targeted therapies. This review considers epigenetic mechanisms as well as recent advances in epigenetic programming in the context of hepatic fibrosis.

Publication metadata

Author(s): Moran-Salvador E, Mann J

Publication type: Review

Publication status: Published

Journal: Cellular and Molecular Gastroenterology and Hepatology

Year: 2017

Volume: 4

Issue: 1

Pages: 125-134

Print publication date: 01/07/2017

Online publication date: 26/04/2017

Acceptance date: 24/04/2017

ISSN (electronic): 2352-345X

Publisher: Elsevier Inc

URL: https://doi.org/10.1016/j.jcmgh.2017.04.007

DOI: 10.1016/j.jcmgh.2017.04.007

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