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Graft-versus-leukemia effect following hematopoietic stem cell transplantation for leukemia

Lookup NU author(s): Professor Anne Dickinson, Jean Norden

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

© 2017 Dickinson, Norden, Li, Hromadnikova, Schmid, Schmetzer and Jochem-Kolb. The success of hematopoietic stem cell transplantation (HSCT) lies with the ability of the engrafting immune system to remove residual leukemia cells via a graft-versus-leukemia effect (GvL), caused either spontaneously post-HSCT or via donor lymphocyte infusion. GvL effects can also be initiated by allogenic mismatched natural killer cells, antigen-specific T cells, and activated dendritic cells of leukemic origin. The history and further application of this GvL effect and the main mechanisms will be discussed and reviewed in this chapter.

Publication metadata

Author(s): Dickinson AM, Norden J, Li S, Hromadnikova I, Schmid C, Schmetzer H, Jochem-Kolb H

Publication type: Review

Publication status: Published

Journal: Frontiers in Immunology

Year: 2017

Volume: 8

Online publication date: 07/06/2017

Acceptance date: 10/04/2017

ISSN (print): 1664-3224

Publisher: Frontiers Research Foundation

URL: https://doi.org/10.3389/fimmu.2017.00496

DOI: 10.3389/fimmu.2017.00496

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