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Genome editing for human osteoarthritis - a perspective

Lookup NU author(s): Dr David Almarza Gomez, Professor John LoughlinORCiD

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Abstract

The ability to efficiently and reproducibly edit genomes using engineered nucleases is one of the major biological advances of the past few decades and is generating considerable excitement for those working in medical research, from investigators studying the molecular and cellular basis of disease through to those generating novel treatments via regenerative medicine and gene therapy. Genome editing is a technology that enables scientists to generate specific DNA modifications at preselected loci in the genome of living cells, with a high degree of specificity and without damaging the cell’s ability to function, replicate or differentiate.

Publication metadata

Author(s): Almarza D, Cucchiarini M, Loughlin J

Publication type: Editorial

Publication status: Published

Journal: Osteoarthritis and Cartilage

Year: 2017

Volume: 25

Issue: 8

Pages: 1195-1198

Print publication date: 01/08/2017

Online publication date: 18/05/2017

Acceptance date: 08/05/2017

ISSN (print): 1063-4584

ISSN (electronic): 1522-9653

Publisher: Elsevier

URL: http://doi.org/10.1016/j.joca.2017.05.003

DOI: 10.1016/j.joca.2017.05.003

PubMed id: 28529161

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