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Targeting the SASP to combat ageing: Mitochondria as possible intracellular allies?

Lookup NU author(s): Dr Jodie Birch, Dr Joao Passos

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

© 2017 WILEY Periodicals, Inc. Anti-senescence therapies, such as drugs that specifically kill senescent cells, to stave off ageing are currently under investigation. While these interventions show promise, their potential pitfalls are discussed herein. We have shown that the mitochondria are essential for development of senescence and many of the associated phenotypes, including the often detrimental senescence-associated secretory phenotype (SASP). Here, we disentangle many ways in which the mitochondria may influence senescence and development of the SASP and focus on possible pathways that could be exploited for future generation of anti-senescence therapies with a clear aim; to specifically eliminate the problematic features of senescent cells, while maintaining their beneficial characteristics.

Publication metadata

Author(s): Birch J, Passos JF

Publication type: Article

Publication status: Published

Journal: BioEssays

Year: 2017

Volume: 39

Issue: 5

Print publication date: 01/05/2017

Online publication date: 20/02/2017

Acceptance date: 02/04/2016

Date deposited: 16/05/2017

ISSN (print): 0265-9247

ISSN (electronic): 1521-1878

Publisher: John Wiley and Sons Inc.

URL: https://doi.org/10.1002/bies.201600235

DOI: 10.1002/bies.201600235

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