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Should we be offering fertility preservation by surgical sperm retrieval to men with Klinefelter syndrome?

Lookup NU author(s): Kevin McEleny, Professor Timothy CheethamORCiD, Dr Richard Quinton

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Abstract

© 2017 John Wiley & Sons Ltd Advances in surgical sperm retrieval have greatly increased the chances of men with Klinefelter syndrome achieving biological paternity. Despite this, the vast majority of attempts to achieve fertility by using extracted gametes to fertilize eggs in vitro do not result in viable pregnancies. A powerful obstacle to success lies with the natural history of seminiferous tubule and germ cell function in Klinefelter syndrome, which typically peak (and thereafter steeply decline) up to a decade before most individuals would be contemplating paternity. Herein we discuss, in relation to a real clinical case, both the exciting technical advances surgical sperm retrieval and the logistic and ethical factors that, in practice, may act to limit their successful application.

Publication metadata

Author(s): McEleny K, Cheetham T, Quinton R

Publication type: Article

Publication status: Published

Journal: Clinical Endocrinology

Year: 2017

Volume: 86

Issue: 4

Pages: 463-466

Print publication date: 01/04/2017

Online publication date: 27/12/2016

Acceptance date: 21/12/2016

ISSN (print): 0300-0664

ISSN (electronic): 1365-2265

Publisher: Blackwell Publishing Ltd

URL: https://doi.org/10.1111/cen.13298

DOI: 10.1111/cen.13298

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