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Intra- and inter-network functional alterations in Parkinson's disease with mild cognitive impairment

Lookup NU author(s): Dr Luis Peraza RodriguezORCiD, Dr Rachael LawsonORCiD, Dr Gordon Duncan, Professor Alison YarnallORCiD, Dr Michael FirbankORCiD, Professor John O'Brien, Professor David BrooksORCiD, Professor David BurnORCiD, Professor John-Paul TaylorORCiD

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This is the authors' accepted manuscript of an article that has been published in its final definitive form by Wiley, 2017.

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Abstract

Mild cognitive impairment (MCI) is prevalent in 15%–40% of Parkinson's disease (PD) patients at diagnosis. In this investigation, we study brain intra- and inter-network alterations in resting state functional magnetic resonance imaging (rs-fMRI) in recently diagnosed PD patients and characterise them as either cognitive normal (PD-NC) or with MCI (PD-MCI). Patients were divided into two groups, PD-NC (N = 62) and PD-MCI (N = 37) and for comparison, healthy controls (HC, N = 30) were also included. Intra- and inter-network connectivity were investigated from participants' rs-fMRIs in 26 resting state networks (RSNs). Intra-network differences were found between both patient groups and HCs for networks associated with motor control (motor cortex), spatial attention and visual perception. When comparing both PD-NC and PD-MCI, intra-network alterations were found in RSNs related to attention, executive function and motor control (cerebellum). The inter-network analysis revealed a hyper-synchronisation between the basal ganglia network and the motor cortex in PD-NC compared with HCs. When both patient groups were compared, intra-network alterations in RSNs related to attention, motor control, visual perception and executive function were found. We also detected disease-driven negative synchronisations and synchronisation shifts from positive to negative and vice versa in both patient groups compared with HCs. The hyper-synchronisation between basal ganglia and motor cortical RSNs in PD and its synchronisation shift from negative to positive compared with HCs, suggest a compensatory response to basal dysfunction and altered basal-cortical motor control in the resting state brain of PD patients.

Publication metadata

Author(s): Peraza LR, Nesbitt D, Lawson RA, Duncan GW, Yarnall AJ, Khoo TK, Kaiser M, Firbank MJ, O'Brien JT, Barker RA, Brooks DJ, Burn DJ, Taylor JP

Publication type: Article

Publication status: Published

Journal: Human Brain Mapping

Year: 2017

Volume: 38

Issue: 3

Pages: 1702-1715

Print publication date: 01/03/2017

Online publication date: 13/01/2017

Acceptance date: 07/12/2016

Date deposited: 04/01/2017

ISSN (print): 1065-9471

ISSN (electronic): 1097-0193

Publisher: Wiley

URL: http://dx.doi.org/10.1002/hbm.23499

DOI: 10.1002/hbm.23499

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