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Actinomadurol, an Antibacterial Norditerpenoid from a Rare Actinomycete, Actinomadura sp KC 191

Lookup NU author(s): Dr Byung-Yong Kim, Professor Michael Goodfellow

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Abstract

A new secondary metabolite, actinomadurol (1), was isolated along with the known compound JBIR-65 (2) from a rare actinomycete, Actinomadura strain KC 191. The structure of 1 was established as a rare member of the bacterial C-19 norditerpenoid class by NMR data and ECD calculations. The absolute configuration of 2, which was previously reported without stereochemical analysis, was determined by using the modified Mosher's method and ECD calculations. Actinomadurol (1) exhibited potent antibacterial activity against pathogenic strains, such as Staphylococcus aureus, Kocuria rhizophila, and Proteus hauseri (MIC = 0.39-0.78 mu g/mL), whereas JBIR-65 (2) showed no antibacterial activity.

Publication metadata

Author(s): Shin B, Kim BY, Cho E, Oh KB, Shin J, Goodfellow M, Oh DC

Publication type: Article

Publication status: Published

Journal: Journal of Natural Products

Year: 2016

Volume: 79

Issue: 7

Pages: 1886-1890

Print publication date: 22/07/2016

Online publication date: 01/07/2016

Acceptance date: 02/04/2016

ISSN (print): 0163-3864

ISSN (electronic): 1520-6025

Publisher: American Chemical Society

URL: http://dx.doi.org/10.1021/acs.jnatprod.6b00268

DOI: 10.1021/acs.jnatprod.6b00268

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