Toggle Main Menu Toggle Search

Open Access padlockePrints

The Newcastle University research output collection, currently available on ePrints, will shortly be moving to a new open repository platform, Figshare. To prepare for the data migration we have paused adding new content to ePrints, and will resume once the new repository is launched. During this time you will continue to have access to ePrints (but no new content will appear). We will share updates here when available.

Calpain-1 is associated with adverse relapse free survival in breast cancer: a confirmatory study

Lookup NU author(s): Dr Despoina Televantou, Dr Nicola Cresti

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

Aims: Calpain-1 is a ubiquitously expressed calcium-activated intracellular cysteine protease. Altered expression of calpain system proteins has been implicated in cancer progression and response to chemotherapy.Methods and results: The aim of the current study was to confirm previous data that suggested that calpain-1 expression is associated with relapse-free survival in trastuzumab-treated breast cancer patients (n = 93). An expanded patient cohort from Nottingham (n = 194; including 72 of the previous cohort) and an independent patient cohort from Newcastle (n = 87) were used. All patients received trastuzumab following adjuvant therapy according to local guidelines with expression of calpain-1 investigated using standard immunohistochemistry. Results show that calpain-1 expression is associated with relapse-free survival in both the Nottingham (P = 0.01) and Newcastle (P = 0.019) cohorts, with high expression associated with adverse relapse-free survival. Expression was also associated with poor relapse-free survival when patient cohorts were combined (n = 281, P = 0.01). Calpain-1 remained, from multivariate analysis, an independent marker for relapse-free survival in the Newcastle cohort [ hazard ratio (HR) = 5.169; 95% confidence interval (CI) 1.468-18.200; P = 0.011].Conclusions: Calpain-1 expression is associated with poor relapse-free survival in breast cancer patients treated with trastuzumab. Further work is warranted to standardize and develop methodology with a view to potentially introducing assessment of this important biomarker into clinical practice.

Publication metadata

Author(s): Pu X, Storr SJ, Ahmad NS, Chan SY, Moseley PM, Televantou D, Cresti N, Boddy A, Ellis IO, Martin SG

Publication type: Article

Publication status: Published

Journal: Histopathology

Year: 2016

Volume: 68

Issue: 7

Pages: 1021-1029

Print publication date: 01/06/2016

Online publication date: 25/10/2015

Acceptance date: 20/10/2015

ISSN (print): 0309-0167

ISSN (electronic): 1365-2559

Publisher: Wiley-Blackwell

URL: http://dx.doi.org/10.1111/his.12896

DOI: 10.1111/his.12896

Altmetrics

Altmetrics provided by Altmetric

Share