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Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells

Lookup NU author(s): Laura Davies, Jennifer Wallis, Dr Paul Waddell, Dr Lee HighamORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

The structural features required for mitochondrial uptake of BODIPY-based optical imaging agents have been explored. The first derivatives of this class of dyes shown to have mitochondrial membrane potential-dependent uptake in both cancer and heart cells have been developed.

Publication metadata

Author(s): Nigam S, Burke BP, Davies LH, Domarkas J, Wallis JF, Waddell PG, Waby JS, Benoit DM, Seymour AM, Cawthorne C, Higham LJ, Archibald SJ

Publication type: Article

Publication status: Published

Journal: Chemical Communications

Year: 2016

Volume: 52

Issue: 44

Pages: 7114-7117

Print publication date: 04/06/2016

Online publication date: 26/04/2016

Acceptance date: 25/04/2016

Date deposited: 15/09/2016

ISSN (print): 1359-7345

ISSN (electronic): 1364-548X

Publisher: Royal Society of Chemistry

URL: http://dx.doi.org/10.1039/C5CC08325G

DOI: 10.1039/c5cc08325g

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Funding

Funder referenceFunder name
High Force Research Ltd
University of Hull
Newcastle University
DAhul0211Daisy Appeal Charity
EP/G005206/1EPSRC

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