Toggle Main Menu Toggle Search

Open Access padlockePrints

The Newcastle University research output collection, currently available on ePrints, will shortly be moving to a new open repository platform, Figshare. To prepare for the data migration we have paused adding new content to ePrints, and will resume once the new repository is launched. During this time you will continue to have access to ePrints (but no new content will appear). We will share updates here when available.

Analysis of causative microorganism in 248 primary hip arthroplasties revised for infection: a study using the NJR dataset

Lookup NU author(s): Dr Richard Holleyman, Paul Baker, Professor David Deehan

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

Introduction: This study aimed to describe the epidemiology of the causative organism in a series of primary hip arthroplasties revised for a diagnosis of periprosthetic joint infection (PJI) in England and Wales.Methods: Patient data from the National Joint Registry (NJR) was linked to microbiology data held by Public Health England (PHE) which identified a series of 248 primary hip arthroplasties revised for PJI between 2003 and 2014. Definitive cultures, isolated at time of revision surgery, were available for all cases. Total hip arthroplasty (n = 239, 96%) and hip resurfacing (n = 5, 2%) were the most commonly performed primary procedures. A two-stage revision was the most common operative management (n = 174, 70%).Results: 202 (81%) cases were infected with a single genus microorganism and the most commonly implicated genus was Staphylococcus species (70% of all single genus infections). Staphylococcus species were also the most commonly identified microorganism in mixed genus infections (74% of patient's cultures). There was a significant difference in microorganism distribution when comparing uncemented vs cement implant fixation, with a higher incidence of Gram-negative infection observed in the uncemented group (p = 0.048, Chi-square).Conclusions: Both prophylactic and therapeutic antibiotic regimes should be focused on targeting Staphylococci.

Publication metadata

Author(s): Holleyman RJ, Baker PN, Charlett A, Gould K, Deehan DJ

Publication type: Article

Publication status: Published

Journal: HIP International

Year: 2016

Volume: 26

Issue: 1

Pages: 82-89

Print publication date: 08/02/2016

Online publication date: 27/01/2016

Acceptance date: 22/09/2015

ISSN (print): 1120-7000

ISSN (electronic): 1724-6067

Publisher: Wichtig Publishing

URL: http://dx.doi.org/10.5301/hipint.5000313

DOI: 10.5301/hipint.5000313

Altmetrics

Altmetrics provided by Altmetric

Share