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A Histogram-Based Similarity Measure for Quantitative Magnetic Resonance Imaging: Application in Acute Mild Traumatic Brain Injury

Lookup NU author(s): Dr Benjamin Aribisala, Christopher CowieORCiD, Dr Jiabao He, Josh Wood, Emeritus Professor David Mendelow, Patrick Mitchell, Professor Andrew BlamireORCiD

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Abstract

Objectives: The most commonly used summary metric in neuroimaging is the mean value, but this pays little attention to the shape of the data distribution and can therefore be insensitive to subtle changes that alter the data distribution.Methods: We propose a distributional-basedmetric called the normalized histogram similarity measure (HSM) for characterization of quantitative images. We applied HSM to quantitative magnetic resonance imaging T-1 relaxation data of 44 patients with mild traumatic brain injury and compared with data of 43 age-matched controls.Results: Significant differences were found between the patients and the controls in 8 gray matter regions using the HSM whereas in only 1 gray matter region based on the mean values.Conclusions: Our results show that HSM is more sensitive than the standard mean values in detecting brain tissue changes. Future studies on brain tissue properties using quantitative magnetic resonance imaging should consider the use of HSM to properly capture any tissue changes.

Publication metadata

Author(s): Aribisala BS, Cowie CJA, He JB, Wood J, Mendelow DA, Mitchell P, Blamire AM

Publication type: Article

Publication status: Published

Journal: Journal of Computer Assisted Tomography

Year: 2014

Volume: 38

Issue: 6

Pages: 915-923

Print publication date: 01/11/2014

Acceptance date: 17/07/2014

ISSN (print): 0363-8715

ISSN (electronic): 1532-3145

Publisher: Lippincott Williams & Wilkins

URL: http://dx.doi.org/10.1097/RCT.0000000000000143

DOI: 10.1097/RCT.0000000000000143

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