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Towards understanding P-gp resistance: a case study of the antitumour drug cabazitaxel

Lookup NU author(s): Dr Ulrich Baisch, Dr Liana Vella-Zarb

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Abstract

A detailed structural study and Hirshfeld surface analysis of cabazitaxel in its anhydrous, hydrated and solvated forms have revealed that the three-dimensional architecture of the drug molecule is retained regardless of the crystalline environment. This prompted comparison with its taxane predecessors, suggesting key factors contributing to cabazitaxel's poor affinity to P-gp.

Publication metadata

Author(s): Baisch U, Vella-Zarb L

Publication type: Article

Publication status: Published

Journal: CrystEngComm

Year: 2014

Volume: 16

Issue: 44

Pages: 10161-10164

Print publication date: 28/11/2014

Online publication date: 01/08/2014

Acceptance date: 01/08/2014

ISSN (print): 1466-8033

Publisher: ROYAL SOC CHEMISTRY

URL: http://dx.doi.org/10.1039/C4CE01279H

DOI: 10.1039/c4ce01279h

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