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Molecular Epidemiology of NDM-1-Producing Enterobacteriaceae and Acinetobacter baumannii Isolates from Pakistan

Lookup NU author(s): Dr Muhammad Raza, Dr John Perry

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Abstract

The molecular epidemiology of 66 NDM-producing isolates from 2 Pakistani hospitals was investigated, with their genetic relatedness determined using repetitive sequence-based PCR (Rep-PCR). PCR-based replicon typing and screening for antibiotic resistance genes encoding carbapenemases, other beta-lactamases, and 16S methylases were also performed. Rep-PCR suggested a clonal spread of Enterobacter cloacae and Escherichia coli. A number of plasmid replicon types were identified, with the incompatibility A/C group (IncA/C) being the most common (78%). 16S methylase-encoding genes were coharbored in 81% of NDM-producing Enterobacteriaceae.

Publication metadata

Author(s): Sartor AL, Raza MW, Abbasi SA, Day KM, Perry JD, Paterson DL, Sidjabata HE

Publication type: Article

Publication status: Published

Journal: Antimicrobial Agents and Chemotherapy

Year: 2014

Volume: 58

Issue: 9

Pages: 5589-5593

Print publication date: 01/09/2014

Online publication date: 30/06/2014

Acceptance date: 21/06/2014

ISSN (print): 0066-4804

ISSN (electronic): 1098-6596

Publisher: American Society for Microbiology

URL: http://dx.doi.org/10.1128/AAC.02425-14

DOI: 10.1128/AAC.02425-14

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