Toggle Main Menu Toggle Search

Open Access padlockePrints

The Newcastle University research output collection, currently available on ePrints, will shortly be moving to a new open repository platform, Figshare. To prepare for the data migration we have paused adding new content to ePrints, and will resume once the new repository is launched. During this time you will continue to have access to ePrints (but no new content will appear). We will share updates here when available.

Endogenous siRNAs: regulators of internal affairs

Lookup NU author(s): Monica Piatek, Dr Andreas Werner

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

Endo-siRNAs (endogenous small-interfering RNAs) have recently emerged as versatile regulators of gene expression. They derive from double-stranded intrinsic transcripts and are processed by Dicer and associate with Argonaute proteins. In Caenorhabditis elegans, endo-siRNAs are known as 22G and 26G RNAs and are involved in genome protection and gene regulation. Drosophila melanogaster endo-siRNAs are produced with the help of specific Dicer and Argonaute isoforms and play an essential role in transposon control and the protection from viral infections. Biological functions of endo-siRNAs in vertebrates include repression of transposable elements and chromatin organization, as well as gene regulation at the transcriptional and post-transcriptional levels.

Publication metadata

Author(s): Piatek MJ, Werner A

Publication type: Article

Publication status: Published

Journal: Biochemical Society Transactions

Year: 2014

Volume: 42

Pages: 1174-1179

Print publication date: 01/08/2014

Acceptance date: 28/03/2014

ISSN (print): 0300-5127

ISSN (electronic): 1470-8752

Publisher: Portland Press

URL: http://dx.doi.org/10.1042/BST20140068

DOI: 10.1042/BST20140068

Altmetrics

Altmetrics provided by Altmetric

Share