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[³H]Nitrendipine binding in temporal cortex in Alzheimer's and Huntington's diseases

Lookup NU author(s): Dr Margaret Piggott, Emeritus Professor Robert PerryORCiD

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Abstract

Specific [H-3]nitrendipine binding which was shown to be calcium- and calmodulin-dependent was found to be significantly reduced in the temporal cortex in Alzheimer's disease compared to age-matched controls. Scatchard analysis revealed that this reduction was due to a loss in the number of cortical [H-3]nitrendipine binding sites rather than a change in the affinity of the binding site in the Alzheimer patients. The reduction in cortical [H-3]nitrendipine-specific binding was most marked in those Alzheimer's disease cases where the duration of the dementing illness was longer than two years. In contrast, no reduction in cortical [H-3]nitrendipine binding was found in Huntington's disease. There was no significant correlation found between age (38-89 years) and [H-3]nitrendipine binding in control cases, or between mean overall plaque counts and [H-3]nitrendipine binding in the Alzheimer's disease cases. There was a significant correlation found between age (46-88 years) and [H-3]nitrendipine binding in the Alzheimer's disease cases where the duration of the dementing illness was greater than two years.

Publication metadata

Author(s): Piggott MA, Candy JM, Perry RH

Publication type: Article

Publication status: Published

Journal: Brain Research

Year: 1991

Volume: 565

Issue: 1

Pages: 42-47

Print publication date: 22/11/1991

ISSN (print): 0006-8993

ISSN (electronic): 1872-6240

Publisher: Elsevier BV

URL: http://dx.doi.org/10.1016/0006-8993(91)91734-I

DOI: 10.1016/0006-8993(91)91734-I

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