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Dermacozines H-J Isolated from a Deep-Sea Strain of Dermacoccus abyssi from Mariana Trench Sediments

Lookup NU author(s): Marcell Wagner, Wael Abdel-Mageed, Professor Alan Bull, Professor Michael Goodfellow

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Abstract

Dermacoccus abyssi sp. nov. strains MT1.1 and MT1.2 are actinomycetes isolated from a Mariana Trench sediment at a depth of 10 898 m. The fermentation process using complex media led to the production of three new Pigmented heteroaromatic (oxidized and reduced) phenazine compounds, dermacozines H-J (1-3). Extensive use was made of ID and 2D NMR experiments and high-resolution MS to determine the structures of the compounds. The new dermacozines showed radical scavenging activity, and the highest activity was observed for dermacozine H (1), with an IC50 value of 18.8 mu M.

Publication metadata

Author(s): Wagner M, Abdel-Mageed WM, Ebel R, Bull AT, Goodfellow M, Fiedler HP, Jaspars M

Publication type: Article

Publication status: Published

Journal: Journal of Natural Products

Year: 2014

Volume: 77

Issue: 2

Pages: 416-420

Print publication date: 05/02/2014

ISSN (print): 0163-3864

ISSN (electronic): 1520-6025

Publisher: American Chemical Society

URL: http://dx.doi.org/10.1021/np400952d

DOI: 10.1021/np400952d

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