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The IL-10/STAT3-mediated anti-inflammatory response: recent developments and future challenges

Lookup NU author(s): Dr Diego Miranda Saavedra

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Abstract

Inflammation is a fundamental response of the immune system whose successful termination involves the elimination of the invading pathogens, the resolution of inflammation and the repair of the local damaged tissue. In this context, the interleukin 10 (IL-10)-mediated anti-inflammatory response (AIR) represents an essential homeostatic mechanism that controls the degree and duration of inflammation. Here, we review recent work on the mechanistic characterization of the IL-10-mediated AIR on multiple levels: from the cataloguing of the in vivo genomic targets of STAT3 (the transcription factor downstream of IL-10) to the identification of specific co-factors that endow STAT3 with genomic-binding specificity, and how genomic and computational methods are being used to elucidate the regulatory mechanisms of this essential physiological response in macrophages.

Publication metadata

Author(s): Hutchins AP, Diez D, Miranda-Saavedra D

Publication type: Article

Publication status: Published

Journal: Briefings in Functional Genomics

Year: 2013

Volume: 12

Issue: 6

Pages: 489-498

Print publication date: 12/08/2013

ISSN (print): 2041-2649

ISSN (electronic): 2041-2657

URL: http://dx.doi.org/10.1093/bfgp/elt028

DOI: 10.1093/bfgp/elt028

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