Toggle Main Menu Toggle Search

Open Access padlockePrints

The Newcastle University research output collection, currently available on ePrints, will shortly be moving to a new open repository platform, Figshare. To prepare for the data migration we have paused adding new content to ePrints, and will resume once the new repository is launched. During this time you will continue to have access to ePrints (but no new content will appear). We will share updates here when available.

The mystery of mitochondrial RNases

Lookup NU author(s): Dr Francesco Bruni, Dr Pasqua Gramegna, Emeritus Professor Robert Lightowlers, Emerita Professor Zofia Chrzanowska-LightowlersORCiD

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

The central dogma states that DNA is transcribed to generate RNA and that the mRNA components are then translated to generate proteins; a simple statement that completely belies the complexities of gene expression. Post-transcriptional regulation alone has many points of control, including changes in the stability, translatability or susceptibility to degradation of RNA species, where both cis- and transacting elements will play a role in the outcome. The present review concentrates on just one aspect of this complicated process, which ultimately regulates the protein production in cells, or more specifically what governs RNA catabolism in a particular subcompartment of human cells: the mitochondrion.

Publication metadata

Author(s): Bruni F, Gramegna P, Lightowlers RN, Chrzanowska-Lightowlers ZMA

Publication type: Article

Publication status: Published

Journal: Biochemical Society Transactions

Year: 2012

Volume: 40

Issue: 4

Pages: 865-869

Print publication date: 01/08/2012

ISSN (print): 0300-5127

ISSN (electronic): 1470-8752

Publisher: Portland Press Ltd.

URL: http://dx.doi.org/10.1042/BST20120022

DOI: 10.1042/BST20120022

Altmetrics

Altmetrics provided by Altmetric

Funding

Funder referenceFunder name
074454/Z/04/ZWellcome Trust
BB/F011520/1Biotechnology and Biological Sciences Research Council

Share