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Brain tissue water comes in two pools: Evidence from diffusion and R2’ measurements with USPIOs in non human primates

Lookup NU author(s): Dr Olivier Joly

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Abstract

Diffusion-weighted MRI of non-human primates revealed that USPIO Bulk Magnetic Susceptibility (BMS) T2’ effects of Ultrasmall Superparamagnetic Particles with Iron Oxide (USPIO) in the brain cannot be explained by a single compartment model, as diffusion and T2’ effects appear coupled: Apparent Diffusion Coefficient (ADC) values depend on USPIO concentration and relaxivity effects of USPIO decrease with the b value. On the other hand, USPIO and diffusion effects could be well uncoupled using a model consisting in a fast and a slow diffusion pool with different relaxivities. Diffusion-weighting acts as a filter which emphasizes the contribution of the slow pool when increasing b values (apparent decrease in ADC and R2’). Those results have implications for human studies using BMS contrast agents, as well as BOLD and diffusion fMRI.

Publication metadata

Author(s): Le Bihan D, Joly O, Aso T, Uhrig L, Poupon C, Tani N, Iwamuro H, Urayama S-I, Jarraya B

Publication type: Article

Publication status: Published

Journal: NeuroImage

Year: 2012

Volume: 62

Issue: 1

Pages: 9-16

Print publication date: 11/05/2012

ISSN (print): 1053-8119

ISSN (electronic): 1095-9572

Publisher: Academic Press

URL: http://dx.doi.org/10.1016/j.neuroimage.2012.05.011

DOI: 10.1016/j.neuroimage.2012.05.011

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