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Suppression of bone turnover by B-cell depletion in patients with rheumatoid arthritis

Lookup NU author(s): Gill Wheater, Dr Vanessa Hogan, Emeritus Professor Roger Francis, Dr Harish Datta, Professor Jaap Van Laar

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Abstract

–cell depletion increases bone formation and decreases bone resorption in rheumatoid arthritis (RA) patients; this may be a direct effect on osteoblasts and osteoclasts, respectively, and be at least partially explained by the decreased inflammation and disease activity.

Publication metadata

Author(s): Wheater G, Hogan V, Teng Y, Tekstra J, Lafeber F, Huizinga T, Bijlsma J, Francis RM, Tuck S, Datta HK, vanLaar J

Publication type: Article

Publication status: Published

Journal: Osteoporosis International

Year: 2011

Volume: 22

Issue: 12

Pages: 3067-3072

Print publication date: 06/04/2011

ISSN (print): 0937-941X

ISSN (electronic): 1433-2965

Publisher: Springer

URL: http://dx.doi.org/10.1007/s00198-011-1607-0

DOI: 10.1007/s00198-011-1607-0

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Funding

Funder referenceFunder name
Axis-Shield diagnostics
Biotest AG
Bristol Myers Squibb
Ely Lilly
JGW Patterson Foundation, Newcastle upon Tyne
Novartis
Schering Plough
Wyeth/Pfizer
Abbott
Roche
Sanofi-Aventis
2008006R&D department at The James Cook University Hospital, Middlesbrough

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