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Pushing and pulling in prokaryotic DNA segregation

Lookup NU author(s): Professor Kenn Gerdes, Florian Szardenings

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Abstract

In prokaryotes, DNA can be segregated by three different types of cytoskeletal filaments. The best-understood type of partitioning (par) locus encodes an actin homolog called ParM, which forms dynamically unstable filaments that push plasmids apart in a process reminiscent of mitosis. However, the most common type of par locus, which is present on many plasmids and most bacterial chromosomes, encodes a P loop ATPase (ParA) that distributes plasmids equidistant from one another on the bacterial nucleoid. A third type of par locus encodes a tubulin homolog (TubZ) that forms cytoskeletal filaments that move rapidly with treadmill dynamics.

Publication metadata

Author(s): Gerdes K, Howard M, Szardenings F

Publication type: Article

Publication status: Published

Journal: Cell

Year: 2010

Volume: 141

Issue: 6

Pages: 927-42

Print publication date: 10/06/2010

ISSN (print): 0092-8674

ISSN (electronic): 1097-4172

Publisher: Cell Press

URL: http://dx.doi.org/10.1016/j.cell.2010.05.033

DOI: 10.1016/j.cell.2010.05.033

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