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Post Cardiac Transplantation Lymphoproliferative Disorder Presenting as t(8;14) Burkitt Leukaemia/Lymphoma Treated With Low Intensity Chemotherapy and Rituximab

Lookup NU author(s): Dr Kevin Windebank, Dr Bridget Wilkins

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Abstract

BackgroundPost-transplant lymphoproliferative disorder (PTLD) occasionally presents as Burkitt lymphoma/L3 leukaemia (BLL).ProcedureWe reviewed records of cases of PTLD post-cardiac transplantation (1990-2007) occurring in our unit.ResultsThere were 15 episodes in 13 patients including four cases of EBV-driven Burkitt-type disease with t(8;14) translocations presenting with advanced stage disease. The first case was treated with a variety of low dose chemotherapy combinations. Despite problems during therapy he obtained complete remission, but died from complications of pre-existing cardiac allograft vasculopathy 7 months later. The subsequent three cases were treated with a UKCCSG low stage lymphoma protocol, NHL 9001 and Rituximab. They remain in complete remission.ConclusionsIn the context of PTLD the prognostic significance of advanced stage EBV-driven BLL with the t(8;14) translocation may be different to that in immunocompetent children.

Publication metadata

Author(s): Windebank KP, Walwyn T, Kirk R, Parry G, Hasan A, Bown N, Wilkins B

Publication type: Article

Publication status: Published

Journal: Pediatric Blood & Cancer

Year: 2009

Volume: 53

Issue: 3

Pages: 392-396

ISSN (print): 1545-5009

ISSN (electronic): 1545-5017

Publisher: John Wiley & Sons, Inc.

URL: http://dx.doi.org/10.1002/pbc.22070

DOI: 10.1002/pbc.22070

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