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Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients

Lookup NU author(s): Dr Kate Potter, Professor John IsaacsORCiD

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Abstract

The introduction of anti-tumour necrosis factor (TNF) agents has greatly improved the treatment of rheumatoid arthritis; however, a significant proportion of patients fall to respond to therapy. We hypothesized that genes within the TNF receptor superfamily member 1 B signalling pathway contribute towards the observed variation in patient response. This was tested by genotyping 73 single-nucleotide polymorphisms (SNPs) from six candidate genes (DUSP1, HRB, IKBKAP, MAP3K1, MAP3K14 and TANK) in a large UK cohort of rheumatoid arthritis patients (n=642). Two SNPs [rs96844(MAP3K1) and rs4792847 (MAP3K14)] showed evidence of association (P

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Author(s): Bowes JD, Potter C, Gibbons LJ, Hyrich K, Plant D, Morgan AW, Wilson AG, Isaacs JD, Worthington J, Barton A, BRAGGSS

Publication type: Article

Publication status: Published

Journal: Pharmacogenetics and Genomics

Year: 2009

Volume: 19

Issue: 4

Pages: 319-323

ISSN (print): 1744-6872

ISSN (electronic): 1744-6880

Publisher: Lippincott Williams & Wilkins

URL: http://dx.doi.org/10.1097/FPC.0b013e328328d51f

DOI: 10.1097/FPC.0b013e328328d51f

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