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Proximicin A, B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete Verrucosispora

Lookup NU author(s): Professor Alan Bull, Professor Michael Goodfellow, Amanda Jones, Dr Luis Maldonado, Wasu Pathom-Aree

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Abstract

A family of three novel aminofuran antibiotics named as proximicins was isolated from the marine Verrucosispora strain MG-37. Proximicin A was detected in parallel in the marine abyssomicin producer "Verrucosispora maris" AB-18-032. The characteristic structural element of proximicins is 4-amino-furan-2-carboxylic acid, a hitherto unknown gamma-amino acid. Proximicins show a weak antibacterial activity but a strong cytostatic effect to various human tumor cell lines.

Publication metadata

Author(s): Fiedler HP, Bruntner C, Riedlinger J, Bull AT, Knutsen G, Goodfellow M, Jones A, Maldonado L, Pathom-Aree W, Beil W, Schneider K, Keller S, Sussmuth RD

Publication type: Article

Publication status: Published

Journal: Journal of Antibiotics

Year: 2008

Volume: 61

Issue: 3

Pages: 158-163

ISSN (print): 0021-8820

ISSN (electronic): 1881-1469

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1038/ja.2008.125

DOI: 10.1038/ja.2008.125

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