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Albidopyrone, a new alpha-pyrone-containing metabolite from marine-derived Streptomyces sp NTK 227

Lookup NU author(s): Claudia Hohmann, Amanda Jones, Professor Michael Goodfellow

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Abstract

Albidopyrone, a new alpha-pyrone-containing secondary metabolite, was produced by Streptomyces sp. NTK 227, a strain isolated from Atlantic Ocean sediment and found to be a member of the Streptomyces albidoflavus 16S rRNA gene clade. The structure of the compound was determined by MS and NMR spectroscopy, and found to have a moderate inhibitory activity against protein-tyrosin phosphatase B.

Publication metadata

Author(s): Hohmann C, Schneider K, Bruntner C, Brown R, Jones AL, Goodfellow M, Krämer M, Imhoff JF, Nicholson G, Fiedler HP, Süssmuth RD

Publication type: Article

Publication status: Published

Journal: Journal of Antibiotics

Year: 2009

Volume: 62

Issue: 2

Pages: 75-79

ISSN (print): 0021-8820

ISSN (electronic): 1881-1469

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1038/ja.2008.15

DOI: 10.1038/ja.2008.15

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Funding

Funder referenceFunder name
SHM-CT-2004-005224European Commission

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