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The low abundance of clonally expanded mitochondrial DNA point mutations in aged substantia nigra neurons

Lookup NU author(s): Dr Amy Reeve, Geoffrey Taylor, Dr Joanna ElsonORCiD, Professor Robert TaylorORCiD, Dr Christopher MorrisORCiD, Emeritus Professor Doug Turnbull

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Abstract

P>Clonally expanded mitochondrial DNA (mtDNA) deletions accumulate with age in human substantia nigra (SN) and high levels cause respiratory chain deficiency. In other human tissues, mtDNA point mutations clonally expand with age. Here, the abundance of mtDNA point mutations within single SN neurons from aged controls was investigated. From 31 single cytochrome c oxidase normal SN neurons, only one clonally expanded mtDNA point mutation was identified, suggesting in these neurons mtDNA point mutations occur rarely, whereas mtDNA deletions are frequently observed. This contrasts observations in mitotic tissues and suggests that different forms of mtDNA maintenance may exist in these two cell types.

Publication metadata

Author(s): Reeve AK, Krishnan KJ, Taylor G, Elson JL, Bender A, Taylor RW, Morris CM, Turnbull DM

Publication type: Article

Publication status: Published

Journal: Aging Cell

Year: 2009

Volume: 8

Issue: 4

Pages: 496-498

Date deposited: 14/06/2010

ISSN (print): 1474-9718

ISSN (electronic): 1474-9726

Publisher: Wiley-Blackwell Publishing Ltd.

URL: http://dx.doi.org/10.1111/j.1474-9726.2009.00492.x

DOI: 10.1111/j.1474-9726.2009.00492.x

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