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The Second-Meal Phenomenon in Type 2 Diabetes

Lookup NU author(s): Dr Ana Jovanovic, Jean Gerrard, Professor Roy Taylor

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Abstract

OBJECTIVE - in health, the rise in glucose after lunch is less if breakfast is eaten. We evaluated the second-meal effect in type 2 diabetes. RESEARCH DESIGN AND METHODS - Metabolic changes after lunch in eight obese type 2 diabetic subjects were compared on 3 days: breakfast eaten, no breakfast, and no breakfast but intravenous arginine 1 h before lunch. RESULTS - Despite comparable insulin levels, the rise in plasma glucose after lunch was considerably less if breakfast had been eaten (0.68 +/- 1.49 vs. 12.32 +/- 1.73 vs. 7.88 +/- 1.03 mmol . h(-1) . l(-1); P

Publication metadata

Author(s): Jovanovic A, Gerrard J, Taylor R

Publication type: Article

Publication status: Published

Journal: Diabetes Care

Year: 2009

Volume: 32

Issue: 7

Pages: 1199-1201

ISSN (print): 0149-5992

ISSN (electronic): 0149-5992

Publisher: American Diabetes Association

URL: http://dx.doi.org/10.2337/dc08-2196

DOI: 10.2337/dc08-2196

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Funding

Funder referenceFunder name
GR073561Wellcome Trust U.K.

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