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Formulation of a coupled mechanism between solute diffusion, phosphatase-kinase reactions and membrane potentials for the primary active transport of phosphorylated substrates through biological membranes

Lookup NU author(s): Dr Ian West

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Abstract

Coupled interrelations occurring between a phosphatase/kinase reaction sequence acting in unstirred layers and on both sides of a charged biomembrane pore structure are presented as a plausible kinetic model for the primary active transport of phosphorylated molecules. Simulations conducted at the cell level and with credible numerical values demonstrate that the enzymes positions strongly regulate the membrane permeability for the transported substrate. Depending on both the enzymes positions (more or less far from the membrane) and the membrane charges, the membrane may appear either impervious, either permeable or able to actively transport a phosphorylated substrate. Globally all happens as if, in function of the enzymes positions, a permanent pore may be regulated, changing from a more closed to a more open conformation. (C) 2002 Elsevier Science Ltd. All rights reserved.

Publication metadata

Author(s): Maisterrena B, Fiaty K, Charcosset C, Perrin B, Couturier R, West IC

Publication type: Review

Publication status: Published

Journal: Progress in Biophysics & Molecular Biology

Year: 2002

Volume: 80

Issue: 3

Pages: 109-137

ISSN (print): 0079-6107

ISSN (electronic): 1873-1732

URL: http://dx.doi.org/10.1016/S0079-6107(02)00016-0

DOI: 10.1016/S0079-6107(02)00016-0

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