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Firing patterns of inferior colliculus neurons-histology and mechanism to change firing patterns in rat brain slices

Lookup NU author(s): Dr Gary Green, Emeritus Professor Adrian ReesORCiD, Dr David Sanders

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Abstract

An in vitro slice preparation was used for intracellular recording from rat central nucleus of inferior colliculus neurons (CNIC). Stable intracellular recordings were made on 184 neurons, 27 of which were successfully stained with ionto-phoresed biocytin. Twenty one of those were classified as flat (F), four as less flat (LF) and the remaining two neurons as unclassified neurons. Recording in response to depolarizing current steps revealed five firing patterns: onset, adapting (regularly and irregularly), regular and bursting. The onset neurons showed non-linear current-voltage (I-V) relationship, whereas the rest had linear current-voltage relationship. Preconditioning hyperpolarizations changed the response pattern of CNIC neurons. It is concluded that there is no anatomy and physiology correlation and the levels of membrane potential may be important in the production of some firing patterns. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

Publication metadata

Author(s): Sanders DJ; Rees A; Green GGR; Bal R

Publication type: Article

Publication status: Published

Journal: Neuroscience Letters

Year: 2002

Volume: 317

Issue: 1

Pages: 42-46

ISSN (print): 0304-3940

ISSN (electronic): 1872-7972

Publisher: Elsevier Ireland Ltd

URL: http://dx.doi.org/10.1016/S0304-3940(01)02425-9

DOI: 10.1016/S0304-3940(01)02425-9

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