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Carnitine palmitoyl transferase I and the control of myocardial beta-oxidation flux

Lookup NU author(s): Professor Kim Bartlett

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Abstract

Carnitine palmitoyltransferase I is assumed to be rate limiting for beta -oxidation in all tissues. However, the concentration of molonyl-CoA in heart and muscle is high and is enough to completely inhibit beta -oxidation if this assumption is correct. In this review, we consider whether: (i) there is a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity; (ii) the measured malonyl-CoA concentration in the heart is physiologically meaningful; and (iii) carnitine palmitoyltransferase I is rate-limiting for beta -oxidation in the heart.

Publication metadata

Author(s): Eaton S, Fukumoto K, Duran NP, Pierro A, Spitz L, Quant PA, Bartlett K

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Biochemical Society Transactions: Colloquium on Fatty Acid Oxidation and Ketone Body Metabolism

Year of Conference: 2001

Pages: 245-250

ISSN: 0300-5127

Publisher: Portland Press Ltd.

Library holdings: Search Newcastle University Library for this item

ISBN: 14708752

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