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Simple standardised neuropsychological assessments aid in the differential diagnosis of dementia with Lewy bodies from Alzheimer's disease and vascular dementia

Lookup NU author(s): Dr Clive Ballard, Professor John O'Brien, Dr Arjun Sahgal, Professor Ian McKeith

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Abstract

Consecutive patients from a dementia case register received a standardised evaluation which incorporated a neuropsychological assessment with the Cambridge Assessment for disorders in the elderly (CAMCOG). Operationalised clinical diagnoses were made (consensus criteria for dementia with Levy, bodies, DLB; NINCDS-ADRDA for Alzheimer's disease, AD, NINCDS AIRENS for vascular dementia, VaD), Two-hundred and twenty-eight patients were studied (DLB 54, AD102, VaD 72), DLB patients had significantly better performance on recent memory than AD patients, but more impaired visuospatial praxis. DLB patients also had significantly better recent memory than those with VaD, Optimal cut-off points for the recent memory:praxis ratio achieved good discrimination between DLB and both other dementias.

Publication metadata

Author(s): McKeith IG; Sahgal A; O'Brien J; Ballard CG; Ayre G; Ince PG; Perry RH

Publication type: Article

Publication status: Published

Journal: Dementia and Geriatric Cognitive Disorders

Year: 1999

Volume: 10

Issue: 2

Pages: 104-108

Print publication date: 01/03/1999

ISSN (print): 1420-8008

ISSN (electronic): 1421-9824

Publisher: S. Karger AG

URL: http://dx.doi.org/10.1159/000017109

DOI: 10.1159/000017109

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